|There is extensive scientific support that mitochondrial function declines with age, probably as early as our twenties. a leading theory on aging, the mitochondrial clock theory, is based upon a gradual decline in mitochondrial function because of DNA damage from reactive oxygen species (ROS) (also known as free radicals). With aging, energy production is reduced. this patented product combines two mitochondrial metabolites and two mitochondrial respiratory chain precursors that enhance mitochondrial function. in animal and human studies these metabolites increase mitochondrial function, enhance energy production and may counteract some of the biochemical reactions associated with aging.
Alpha lipoic acid: (150 mg)
Alpha lipoic acid (ALA) is a coenzyme necessary for normal mitochondrial function and energy production. This vitamin-like substance has been supplemented orally for health benefits and has also been used as a therapeutic agent in a variety of liver and brain disorders, as well as mushroom poisoning. Consideration has also been given to the use of ALA in the treatment of diabetes and recent studies in our laboratory have demonstrated improvement in age related hearing loss (Seidman et al in press). We have also shown its ability to enhance mitochondrial function (safely), which allows for increased energy production.
Dietary supplementation of ALA successfully prevents heart damage induced by reduced blood supply as is seen in heart attacks. Presently its primary therapeutic use is for the treatment of diabetic induced nerve dysfunction (neuropathy). The reduced form of alpha-lipoic acid is dihydrolipoic acid (DHLA). DHLA prevents lipid peroxidation which is the end stage of free radical damage. It does this by reducing glutathione which in turn recycles vitamin E. DHLA has also been demonstrated to be a reactive oxygen metabolite scavenger (an antioxidant), to reduce peroxyl, ascorbyl and chromanoxyl radicals and to inhibit singlet oxygen (these are all beneficial effects).
Acetyl L-carnitine: (600 mg)
Acetyl L-carnitine (ALCAR) is a biological compound which plays a key role in the transport of fatty acids from inside the cell to the mitochondria for beta-oxidation. This is a crucial step for energy production. ALCAR controls the metabolism of sugars, lipids and amino acids, thus playing a pivotal role in cellular energy and turn over of cell membranes and proteins. A positive effect on survival was observed in rats treated with ALCAR (Markowska et al 1990). The mechanisms of this effect are currently unknown, but they are very similar to the survival observed in rats fed a restricted caloric diet. Chronic treatment with ALCAR enhances stimulation of antioxidant defenses. It also enhances the age-related effect of glucocorticoid secretion, and improves learning and memory possibly due to its ability to increase the release of acetylcholine. Pretreatment of old rats with ALCAR was able to bring back the levels of mitochondrial transcripts to adult levels in a time and dose-dependent fashion. Furthermore, studies in our laboratory have shown improved hearing in aged subjects compared to controls. Additionally, the treated subjects had improved mitochondrial function, energy production and there was evidence for a reduction in mitochondrial damage (Seidman et al Am J of Otol 2000).
ALCAR is capable of restoring the integrity of the cardiac mitochondrial membrane altered by aging (specifically the cardiolipin content), thereby restoring the normal activity of cytochrome oxidase, adenine nucleotide translocase, and phosphate carrier. This allowed more efficient energy production and results in improved cardiac performance in the aged.
Coenzyme Q-10: (90 mg)
Coenzyme Q-10 (CoQ-10) is crucial for mitochondrial function and is essential in the generation of energy. It was first recognized in 1957 as a component necessary for oxidative phosphorylation (the process by which the mitochondria makes energy). Reduced CoQ-10 functions as an antioxidant and can therefore combat the production of free oxygen radicals. Additionally, it appears to function by preventing the initiation and propagation of lipid peroxidation (the end stage of free radical damage). There is evidence supporting an age-related decline of CoQ-10 in humans and other species, thus further supporting the membrane hypothesis of aging. CoQ-10 is currently used alone or in combination as a health/nutritional supplement. It has shown promise in enhancing heart function and has been used medicinally in European countries for this purpose. In this regard, it is gaining momentum in the USA. It may also be useful in cognitive and other neurologic disorders (i.e. Alzheimer's disease and diseases that produce muscle weakness such as certain muscular dystrophies).
Glutathione: (60 mg)
Glutathione (L-K-glutamyl-L-cysteinyl-glycine; GSH) detoxifies reactive oxygen species (it acts as an antioxidant). It is also involved in the metabolism and detoxification of certain drugs. Mitochondrial glutathione is critical to cell viability and the glutathione redox cycle is a primary antioxidant defense system within the mitochondrial membrane. Additional functions include intracellular binding, transport of lipophilic substances and prostaglandin synthesis.
Many studies have demonstrated that alterations of glutathione levels through excess or reduced production have a beneficial or harmful influence on cellular function, respectively. Specifically, it has been shown that glutathione reduces gentamicin induced cochlear damage and that gentamicin ototoxicity may be attenuated using glutathione. It has also been shown that the mechanism for toxicity of certain clinically used drugs occurs secondary to reduced glutathione levels with an increase in reactive oxygen species. Studies have demonstrated an age-associated 86% reduction in glutathione levels in the auditory nerve. Thus, it can be hypothesized that hearing loss may occur in part because of reduction in glutathione levels with age.
Studies of patients with Alzheimer?s disease have demonstrated age-dependent decreases of glutathione-peroxidase activities and their cofactors.
These supplements are made with the finest natural ingredients. Several of the ingredients cannot be obtained from natural sources and then only the highest quality manufactured ingredients are used. An example is acetyl-l-carnitine which can be found in small quantities in broccoli, but approximately 15 pounds would have to be ingested to obtain the amounts provided in our patented Anti-age/Energy Formula.
None of our supplements contain any yeast, sugars, preservatives, artificial coloring, artificial flavoring, wheat, corn, or milk.
The supplements are made in a FDA inspected laboratory that meets all requirements of safety and sterility.
These supplements meet or exceed all USP specifications.
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