Anti-Age/Energy Formula Claims Info

Directions: Take two Anti-age/Energy capsule daily with 8 oz. of water and with a meal (60 cnt = 1 month supply). Note this patented formula is somewhat acidic and may cause heartburn in <5% of users. If you experience heartburn please drink one more full glass of water and the problem will resolve. If you are taking the Anti-age/Energy formula, the Antioxidant formula and the Multivitamin formula, (our recommendation) we suggest taking the supplements as follows:
1 MVI;1 Antioxidant;1 Anti-age in the AM and 2MVI, 1 Antioxidant and 1 Anti-age in the PM If you cannot remember your evening dose, it is okay to take it all at once, however it is best if you can space out the dosing.

Ingredients: (two capsules contains)
 
%Daily Value
Acetyl-L-Carnitine
600 mg
*
Alpha Lipoic acid
150 mg
*
Co-enzyme Q-10
90 mg
*
L-Glutathione
60 mg
*
* Daily value not established
   

Claims:

1.Enhances mitochondrial function and thereby improves efficiency of adenosine triphosphate production (ATP) (Energy production)1,2,3

2.Preliminary data demonstrates repair of mitochondrial DNA deletions (MtDNA del). Specifically, repairs the common aging deletion (MtDNA del4977 in humans) and (MtDNA del4834 in rats)4,5

3.Acetyl-L-Carnitine and Alpha Lipoic Acid reverse age related hearing loss in rats
6

4.In higher doses, ie three-four pills per day, there can be improvement in patients with Alzheimer's disease and other cognitive disorders7,8,9,10,11,12,13

5. This supplement functions to slow some of the processes of aging
14,15,16,17,18,19,20,21

References:

1. Seidman et al, unpublished data-1, 1999

2. Kelly GS. Sports Nutrition: A review of selected nutritional supplements for endurance athletes. Alternative Medicine Review, 2(4):282-95, 1997

3. Maresh CM, et al. Dietary supplementation and improved anaerobic performance. Int J Sport Nutri, 4(4):387-397, 1994

4. Seidman MD, Bai U, Khan MJ and Quirk WS. Mitochondrial DNA Deletions Associated with Aging and Presbyacusis. Arch Otolaryngol., 1997

5. Bai U, Seidman MD, Hinojosa R, Quirk WS. Mitochondrial DNA Deletions Associated with Aging and Possibly Presbyacusis: A Human Archival Temporal Bone Study. Am J. Otology. 18:449-453, 1997

6. Seidman MD, Khan MJ, Bai U, Shirwany N, Quirk WS. Influence of Mitochondrial Metabolite Supplements on Age-Related Hearing Loss. In press.

7. Anneren G, Gardner A, Lundin T. Increased glutathione peroxidase activity in erythrocytes in patients with Alzheimer?s disease/senile dementia of Alzheimer?s type. Acta Neurol Scnd Jrl; 73(6):586-589, 1986

8. Applequist E, Kalen A, Dallner G. Biosynthesis and regulation of coenzyme Q, in Folkers K, Littaru G, Yamagami T (eds), Biomedical and clinical aspects of coenzyme Q. Amsterdam, Elsevier, vol 6, pp 141-150, 1991

9. Dimpfel W, Spuler M, Pierau FK, Ulrich H. Thioctic Acid Induces Dose-Dependent Sprouting of Neurites in Cultured Rat Neuroblastoma Cells. Dev Pharmacol Ther. 14(3):193-99, 1990

10. Fariello RG, Ferraro TN, Golden GT, DeMattei M. Systemic Acetyl L-Carnitine Elevates Nigral Levels of Glutathione and GABA. Life Sciences. 43(3): 289-292, 1988

11. Hayn M, Kremser K, Singewald N, Cairns N, Nemethova M, Lubec B, Lubec G. Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down?s syndrome and Alzheimer?s disease. Life Sci 59(7):537-544, 1996

12. Imperato A, Ramacci MT, Angelucci L. Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 17:251-255, 1989

13. Markowska AL, Olton DS. Dietary Acetyl-L-carnitine improves spatial behavior of old rats. Int. J Clin Pharmacol Res. 10:65-68, 1990

14. Beyer RE, Nordenbrand K, Ernster L. The function of coenzyme Q in free radical production and as an antioxidant: a review. Chem Scripta. 27:145-153, 1987

15. Bandy B and Davison AJ. Mitochondrial Mutations May Increase Oxidative Stress: Implications for Carcinogenesis and Aging? Free Radical Biol Med. 8(6):523-39, 1990

16. Ames BN, Shigenaga MK, Hagen TM. Mitochondrial decay in aging. Biochim Biophys Acta. 1271(1): 165-170, 1995

17. Gadaleta MN, Petruzella V, Daddabbo L, Olivieri O, Fracasso P, Longuericio Polosa P, Cantatore P. Mitochondrial DNA Transcription and Translation in Aged Rats. Effect of Acetyl-L-Carnitine. Ann. NY Acad. Sci. 717:150-160. 1994

18. Halliwell B and Chirico S. Lipid Peroxidation: It?s Mechanism, Measurement, and Significance. Am J Clin Nutr. 47(S):715S-725S, 1993

19. Lonnrot K, Metsa-Ketela T, Alho H. The Role of Coenzyme Q-10 in aging: a follow up study on life long oral supplementation Q-10 in rats. Gerontology 41(2):109-120. 1995

20. Paradies G, Ruggiero FM, Petrosillo G, Gadaleta MN, Quagliariello E. Effect of Aging and Acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. FEBS Lett. 350:213-215, 1994

21. Suzuki YJ, Tsuchiya M, Parker L. Thioctic Acid and Dihydrolipoic Acid are Novel Antioxidants which Interact with Reactive Oxygen Species. Free Radio Res Comm. 14:255-263,1991

Please note: Body Language Vitamin Co and/or Michael D. Seidman, MD, FACS reserve all rights to this proprietary information. Any use of this information without the express written consent of BLV Co or Michael D. Seidman, MD is considered a violation of copyright/trademark laws and persons knowingly or unknowingly found guilty of copying or using this information will be punished to the fullest extent of the law.